Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat
Sari
Effects of polyvinylpyrrolidone K-30 on dissolution characteristics of solid dispersion systems have been studied. Solid dispersions were prepared by solvent method using several ratios of ketoprofen-polyvinylpyrrolidone K-30 as follows 1:9, 3:7, 5:5, 7:3, 9:1. Physical mixtures of ketoprofen-polyvinylpyrrolidone K-30 were used as a comparison. The solid dispersion systems and physical mixtures were evaluated for physicochemical properties and dissolution characteristics. Dissolution tests were measure with modified basket method using pH 7.2 phosphate buffer as dissolution medium. Samples were taken up after 5, 10, 15, 20, 30, 45, and 60 minutes. Results generally showed that solid dispersion system of ketoprofenpolyvinylpyrrolidone K-30 have a different physicochemical properties compared to physical mixtures and pure ketoprofen and exhibited better dissolution rate and dissolution efficiency of ketoprofen. Dissolution efficiency and dissolution rate constant of the solid dispersion system were 59.41%, and 1.66 mg/s, respectively.
Teks Lengkap:
PDF (English)Referensi
Abdou. HM, Dissolutions Bioavailability and Bioequivalence, Mark Publishing Co, 1989
Ansel, H. C., Intoduction to Pharmaceutical Dosage Form, 4th Ed, Pengantar Bentuk Sediaan Farmasi, diterjemahkan oleh Farida Ibrahim, UI Press, Jakarta, 1989
Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia, Farmakologi dan Terapi, Gaya Baru, Jakarta, 1995 Banakar, U. V., Pharmaceutical Dissolution Testing, Marcel Dekker, INC, USA, 1992
Ben, E. S., Salman, & Y. Syukri, Studi Sistem Dispersi Padat Furosemid-Urea, J. Sains & Tek Far, 3(1), 1998 : 12
Blacow, Norman W, Martindale the Extra Pharmacopoeia, 26th Ed, The Pharmaceutical Press, London, 1972
Chiou, W. L. & S.Riegelman., Pharmaceutical Aplication of Solid Dispersion System, J. Pharm, Sci., 60 (9), 1281, 1971
Farmakope Indonesia, Edisi III, Departemen Kesehatan Republik Indonesia, Jakarta, 1979 Farmakope Indonesia, Edisi IV, Departemen Kesehatan Republik Indonesia, Jakarta, 1995
Halim, A., Teknologi Partikel, Univesitas Andalas, Padang, 1991 Lachman, L.H.A., Lieberman & J.L Kanig, Teori dan Praktek Farmasi Industri Ed III, UI Press, Jakarta, 1994
Martin, E.W., E.F. Cook., E.E. Leuallen., A. Osol., Linwood, F.T., & T.V.M Clarence, Remington’s Practice of Pharmacy, 12th Ed, Mack Publishing Company, Pensylvania, 1961
Martin, A., J. Swabrick & A. Cammarata, Farmasi Fisik, diterjemahkan oleh Yoshita, Edisi III., Universitas Indonesia Press, Jakarta, 1990 Save, T. & P. Venkitachalam., Studies on Solid Dispersions of Nipedipine, Drug Dev. & Ind. Pharm., 18 (15), 1992 : 1663-1679
Swabrick, J., & C.B. James, “Copresipitates and Melt”, Encyclopedia of Pharmaceutical Technology, Volume 3, Marcel Dekker Inc, New York, 1990
Shargel, L. & B.C. Yu, Andrew, Biofarmasetika dan Farmakokinetik Terapan Edisi kedua, diterjemahkan oleh Fasich, Unair Press, Surabaya, 1998
Voight, R., Buku Pelajaran Teknologi Farmasi ed V, diterjemahkan oleh Soendari Noerono, Gajah Mada University Press, Yogyakarta, 1994
Wade, A & Paul J. W., Handbook of Pharmaceutical Excipient, 2nd Ed. The Pharmaceutical Press, London, 1994
DOI: http://dx.doi.org/10.52689/higea.v1i1.2
Refbacks
- Saat ini tidak ada refbacks.
##submission.license.cc.by-nc-sa4.footer##