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UJI AKTIVITAS SITOTOKSIK KATEKIN DARI DAUN GAMBIR (Uncaria gambir (Hunter) Roxb.) TERHADAP SEL MCF-7 | Bakhtra | Jurnal Farmasi Higea

UJI AKTIVITAS SITOTOKSIK KATEKIN DARI DAUN GAMBIR (Uncaria gambir (Hunter) Roxb.) TERHADAP SEL MCF-7

Dwi Dinni Aulia Bakhtra, Nifira Sakinah, Aried Eriadi

Sari


Kanker payudara merupakan salah satu jenis kanker yang paling mematikan bagi wanita. Pengobatan dengan kemoterapi sering menimbulkan efek samping yang merugikan. Katekin dari daun gambir (Uncaria gambir (Hunter) Roxb) memiliki aktivitas sitotoksik serta antioksidan yang pontensial. Penelitian ini bertujuan untuk mengetahui pengaruh katekin terhadap pertumbuhan sel kanker dan aktivitas sitotoksik terhadap sel MCF-7 menggunakan MTT Assay. Dari hasil penelitian katekin dari daun gambir (Uncaria gambir (Hunter) Roxb) mempengaruhi pertumbuhan sel MCF-7 (p<0.05). Dari hasil analisis dengan persamaan regresi, nilai IC50 17,7 μg/mL, yang berada dalam kategori sitotoksik aktif (IC50<30 mg/mL). Dari hasil penelitian dapat disimpulkan bahwa katekin dari Uncaria gambir memiliki aktivitas sitotoksik aktif dan berpotensi untuk dikembangkan dalam terapi alternatif pengobatan kanker payudara

Kata Kunci


Katekin; Uncaria gambir; MCF-7; MTT

Teks Lengkap:

PDF

Referensi


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Aditya, M., Ariyanti, P. R. 2016. Manfaat gambir (Uncaria gambier Roxb) sebagai Antioksidan. Jurnal Majority Universitas Lampung, 5(3) 129-133.

Bakthra, D. D. A., Uyun, H. S. K., Eriadi, A., Fajrina, A., Wiliantari, S., Praciska, W., Wandani, J. D. 2023. Pengaruh pemberia katekin Terhadap Pemberian Kultur Sel Kanker Servik. Jurnal Farmasi Higea,15 (2), 163- 170.

Bakhtra, D.D.A., Fajrina, A., Ameliona, P. 2024. Uji aktivitas sitotoksik ekstrak n-heksan daun alpukat (Persea americana Mill) terhadap sel kanker kulit B16f0 dengan metode microculture tetrazolium test. Jurnal farmasi higea, 16(1):6-10.

Hosseini, A & Ghorbani, A. 2015. Cancer Therapy with Phytochemicals: evidence from clinical studies. Avicenna J Phytomed, 5 (2): 84-97.

International Agency for Research on Cancer. GLOBOCAN (2020). Indonesia Global Cancer Observatory. diakses 27 Oktober 2022 dari : https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf.

Isnawati, A., Raini, Ma., Sampurno, O. D., Mutiatikum, D., Widowati, L., Gitawati, R. 2012. Karakterisasi Tiga Jenis Ekstrak Gambir (Uncaria gambir Roxb) Dari Sumatera Barat. Bul. Penelit. Kesehat, 40(4): 201 – 208.

Kementerian Kesehatan Republik Indonesia. 2017. Acuan Bahan Baku Obat Tradisional dari Tumbuhan Obat Di Indonesia. Jakarta: Direktorat Jenderal Kefarmasian dan Alat Kesehatan.

Ediningsih., & Rahayuningsih, S. 2019. Extraction, Isolation, Characterisation and Antioxidant Activity Assay of Catechin Gambir (Uncaria gambir (Hunter). Roxb. Al-Kimia, 7(2): 177-188. https://doi.org/10.24252/al-kimia.v7i2.7800

Nurhayati, A.P.D., Nurlita, A. & Rachmat, F. 2006. Uji Toksisitas Ekstrak Eucheuma Alvarezii terhadap Artemia salina sebagai Studi Pendahuluan Potensi Anti Kanker. Akta Kimindo, 2(1) : 118.

Polite, B. N., Adams-Campbell, L. L., Brawley, O. W., Bickell, N., Carethers, J. M., Flowers, C. R, et al. 2017. Charting the future of cancer health disparities research: A position statement from the American association for cancer research, the American cancer society, the American society of clinical oncology, and the national cancer institute. CA Cancer J Clin, 67(5):353-61.

Pramanik, F., Satari, M. H., Azhari, A. 2023. Cytotoxic Activity of Gambier Leave (Uncaria gambir) Ethyl Acetate Extract on Mouse Embryonic Fibroblast Cell (NIH-3T3) using MTT Assay. The Open Dentistry Journal, 17: 1-6.

Rahmaddiansyah, R., Hasani, S., Zikrah, A.A., & Arisanty, D. (2022). The Effect of Gambier Catechin Isolate on Cervical Cancer Cell Death (HeLa Cell Lines). Open Access Macedonian Journal of Medical Sciences, 10(B), 1293–1297. https://doi.org/10.3889/oamjms.2022.8779

Saganuwan, S. A. 2021. Application of modified Michaelis-Menten equations for determination of enzyme-inducing and inhibiting drugs. BMC Pharmacol Toxicol, 22(1):57.

Sari, L. M. (2018). Apoptosis: Mekanisme Molekuler Kematian Sel. Cakradonya Dental Journal, 10(2), 65-70.

Shimizu, H., Schredelseker, J., Huang, J., Lu, K., Naghdi, S., Lu, F., Franklin, S., Fiji,H.D.G., Wang, K., Zhu, H., Tian, C., Lin, B., Nakano, H., Ehrlich, A., Nakai, J., Stieg, A.Z., Gimzewski, J.K., Nakano, A., Goldhaber, J.I., Vondriska, T.M., Hajnoczky, G., Kwon, O., Chen, J.N. (2015). Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. eLife, 4: e04801. DOI: 10.7554/eLife.04801.

Stahl, E. (1985). Analisis obat secara kromatografi dan mikroskopi. Bandung : ITB, 3-4.

Standar Nasional Indonesia. (2000). Gambir. Jakarta : Badan Standarisasi Nasional. SNI 01-3391-2000.

Widiyarti, G., Sundowo, A., Filailla, E., & Laksmono, J. A. 2020. The Mechanically Extraction Process from Leaves and Twigs of Gambier ( Uncaria gambier Roxb ) and Its Antioxidant Activity. J. Pure App. Chem. Res, 9(1): 8–15.

Yeni, G., Syamsu, K., Suparno, O., Mardliyati, E., & Muchtar, H. (2014). Repeated Extraction Process Of Raw Gambiers (Uncaria Gambir Robx.) For Thecatechin Production As An Antioxidant. International Journal of Applied Engineering Research, 9(24), 24565–24578




DOI: http://dx.doi.org/10.52689/higea.v17i1.693

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