Penggunaan Kombinasi Pati Bengkuang – Avicel PH101 Sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung

Syofyan Syofyan, Ezi Afri Yelni, Rieke Azhar

Sari


Starch yam bean (Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability and compressibility which can not be used as diluents of direct tablet compression. The purpose of this research is to know the influence of the combination avicel PH101-starch as a filler material co-process. Tablet made with direct compression method with isoniazid as a model drug. Results of the study show that the formula 4 (Avicel PH101 concentration with 4%) can produce co-process with mechanical and physical properties of compresibilitas-the most good, as for the evaluation of isoniazid tablets do not meet the requirements of violence and friabilytas on all formula. In summary, use of Co-Process yam bean starch-Avicel PH101 with 0-4% Avicel PH101 concentration was not produced a tablet that meet the requirements.


Kata Kunci


isoniazid, avicel PH101, co-process, yam bean starch, direct compression tablet.

Teks Lengkap:

PDF (English)

Referensi


Ben, E. S., 2008, Teknologi tablet, Padang: Andalas University Press.

Departemen Kesehatan Republik Indonesia, 1995, Farmakope indonesia (Edisi 4), Jakarta: Dirjen POM Departemen Kesehatan Republik Indonesia.

Departemen Kesehatan Republik Indonesia, 1979, Farmakope indonesia (Edisi 3), Jakarta: Dirjen POM Departemen Kesehatan Republik Indonesia.

Gohel, M.C. & Jogani, P.D., 2005, A Review of Coprocess Directly Compressible Excipients. J. Pharm Sci, 8(1): 76-93.

Hauscild, K & Picker., 2004, Evaluation of New Coprocess Compound Based on Lactose and Maize Starch for Tableting Formulation, Pharm, Sci Tech, 6(2): 16.

Jufri, M., Dewi, R., Ridwan, A., & Firli., 2006, Studi Kemampuan Biji Pati Durian Sebagan Bahan Pengikat dalam Tablet Ketoprofen Secara Granulasi Basah, Majalah Ilmu Kefarmasian, 3(2): 78-86.

Nelrahmi, 2001, Penggunaan Pati Bengkuang (Pachyrrizuserosus Urban) Pragelatinasi sebagai Bahan Pembantu Pembuatan Tablet Asam Askorbat Secara Cetak Langsung, Skripsi, Padang: Universitas Andalas.

Voigt, R., 1994, Buku Pelajaran Teknologi Farmasi (Edisi 5), Jakarta: Universitas Gajah Mada.

Wicaksono, Y. & Syifa’, N., 2008, Pengembangan Pati Singkong-Avicel PH 101 menjadi Bahan Pengisi Co-Process Tablet Cetak Langsung, Majalah Farmasi Indonesia, 19(4): 165-171.




DOI: http://dx.doi.org/10.52689/higea.v5i1.75

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