ojs2 has produced an error Message: CAUGHT EXCEPTION: ini_set(): Cannot set 'user' save handler by ini_set() or session_module_name() In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/session/SessionManager.inc.php At line: 37 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of GenericPlugin::manage($verb, $args, &$message, &$messageParams) should be compatible with PKPPlugin::manage($verb, $args, &$message, &$messageParams, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/plugins/GenericPlugin.inc.php At line: 58 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of WebFeedPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/webFeed/WebFeedPlugin.inc.php At line: 147 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of TinyMCEPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/tinymce/TinyMCEPlugin.inc.php At line: 425 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of CustomBlockManagerPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/customBlockManager/CustomBlockManagerPlugin.inc.php At line: 72 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of StaticPagesPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/staticPages/StaticPagesPlugin.inc.php At line: 83 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of AcronPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/acron/AcronPlugin.inc.php At line: 87 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of AcronPlugin::manage($verb, $args, &$message) should be compatible with GenericPlugin::manage($verb, $args, &$message, &$messageParams) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/acron/AcronPlugin.inc.php At line: 104 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of UsageEventPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/usageEvent/UsageEventPlugin.inc.php At line: 79 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ReferralPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/referral/ReferralPlugin.inc.php At line: 44 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of UsageStatsPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/usageStats/UsageStatsPlugin.inc.php At line: 186 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ReportPlugin::manage($verb, $args) should be compatible with PKPPlugin::manage($verb, $args, &$message, &$messageParams, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/classes/plugins/ReportPlugin.inc.php At line: 231 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ArticleHandler::validate(&$request, $articleId, $galleyId = NULL) should be compatible with PKPHandler::validate($requiredContexts = NULL, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php At line: 412 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ArticleHandler::setupTemplate($request) should be compatible with PKPHandler::setupTemplate() In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php At line: 542 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php:41)
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php:42)
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/handler/PKPHandler.inc.php:254)
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/handler/PKPHandler.inc.php:259)
ojs2 has produced an error Message: WARNING: Parameter 2 to ArticleHandler::view() expected to be a reference, value given In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/core/PKPRouter.inc.php At line: 362 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of InstitutionalSubscription::isValid($domain, $IP, $check = SUBSCRIPTION_DATE_BOTH, $checkDate = NULL) should be compatible with Subscription::isValid($check = SUBSCRIPTION_DATE_BOTH, $checkDate = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/classes/subscription/InstitutionalSubscription.inc.php At line: 121 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of CitationDAO::getInsertId() should be compatible with DAO::getInsertId($table = '', $id = '', $callHooks = true) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/citation/CitationDAO.inc.php At line: 463 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of PubIdPlugin::manage($verb, $args) should be compatible with PKPPlugin::manage($verb, $args, &$message, &$messageParams, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/classes/plugins/PubIdPlugin.inc.php At line: 77 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of DOIPubIdPlugin::getPubId(&$pubObject, $preview = false) should be compatible with PubIdPlugin::getPubId($pubObject, $preview = false) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/pubIds/doi/DOIPubIdPlugin.inc.php At line: 68 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Cannot modify header information - headers already sent by (output started at /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/core/PKPApplication.inc.php:381) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/template/PKPTemplateManager.inc.php At line: 340 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Cannot modify header information - headers already sent by (output started at /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/core/PKPApplication.inc.php:381) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/template/PKPTemplateManager.inc.php At line: 343 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of InformationBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/information/InformationBlockPlugin.inc.php At line: 47 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of AuthorBiosBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/authorBios/AuthorBiosBlockPlugin.inc.php At line: 47 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of NotificationBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/notification/NotificationBlockPlugin.inc.php At line: 60 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of SubscriptionBlockPlugin::getContents(&$templateMgr, $request) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/subscription/SubscriptionBlockPlugin.inc.php At line: 49 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of LanguageToggleBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/languageToggle/LanguageToggleBlockPlugin.inc.php At line: 81 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of WebFeedBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/webFeed/WebFeedBlockPlugin.inc.php At line: 98 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen – Polivinil Pirolidon K-30 | Umar | Jurnal Farmasi Higea

Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen – Polivinil Pirolidon K-30

Salman Umar, Nella Vista Sari, Rieke Azhar

Sari


The study of physical and chemical stability of solid dispersion ketoprofen-PVP K-30 has been studied. The solid dispersions system were prepared by solvent method with several variation amount. Ketoprofen-PVP K-30 was evaluated by its physicochemical properties using the Differential Thermal Gravimetric (DTG), FT-IR spectroscopy and dissolution profiles. This study used an accelerated stability test at temperature (40±2)˚C for 3 months. The test include organoleptic test and ketoprofen content. Ketoprofen content were measured by UV spectrophotometer at 255.5 nm, respectively, after were stored for 1, 2 and 3 months at a temperature (40±2)˚C. The analysis of DTG showed endothermic peak friction ketoprofen is significant. FT-IR spectra indicated no chemical interaction between ketoprofen-PVP K-30 in the solid dispersion. The result showed that solid dispersion of ketoprofen with PVP K-30 gave a good physicochemical characterization of ketoprofen and could improve the dissolution rate of ketoprofen. Formula 3 of solid dispersion shown  the highest dissolution rate at 30 minute (82.657%) ( not less than 80%). The chemical and physical stability of solid dispersion of ketoprofen-PVP K-30, indicating change in the physics and chemistry of solid dispersions. The organoleptic test also showed discoloration of the three formulas and third assay formula showed that increasing the concentration of PVP-K-30 in the solid dispersion will lead to decreased content of ketoprofen. In addition, the most stable formula is a formula 1 with a ratio of 1:1 which resulted usage of 29 months.

Kata Kunci


Ketoprofen; solid dispersion; PVP K-30; stability

Teks Lengkap:

PDF (English)

Referensi


ojs2 has produced an error Message: WARNING: Declaration of MetadataDescriptionDAO::getInsertId() should be compatible with DAO::getInsertId($table = '', $id = '', $callHooks = true) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/metadata/MetadataDescriptionDAO.inc.php At line: 166 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve

Agoes G. (2001). Studi stabilitas sediaan farmasi. Bandung: Teknologi Farmasi Program Pascasarjana, Institut Teknologi Bandung.

Azhar, R.,Suardi, M.,&Umar, S. (2009). Pengaruh polivinylpirolidon K-30 terhadap disolusi ketoprofen dalam sistem dispersi padat. Jurnal farmasi higea. Vol 1 (1), 6-13.

Chowdary, K.P.R., Adinarayana, T., Vijay, T & Moyya, M.R.P. (2013). A Factorial Study on The Enchancement of Dissolution Rate of Ketoprofen by Solid Dispersion in Combined Carriers. Journal of Global Trends in Pharmaceutical Sciences, 4, 1163.

Departemen Kesehatan Republik Indonesia. (1995). Farmakope Indonesia edisi IV, Jakarta.

Fudholi, A. (2013). Disolusi dan Pelepasan Obat In Vitro. Yogyakarta: Pustaka Pelajar

Gennaro, A. R. (1985). Remington pharmaceutical sciences. (17th ed). Easton: Mack Publishing Company.

Lachman, L., H. A. Lieberman & Kanig, J. L. (1994). Teori dan praktek farmasi industri I (Edisi II). Penerjemah: S. Suryatmi. Jakarta: Universitas Indonesia Press.

Martin, A ., Swarbrick, J & Cammaratta, A (1993). Farmasi fisik (Edisi III) . Penerjemah: Yoshita. Jakarta: Universitas Indonesia Press.

Patil, S., Sherikar, A., Patil, S & Patil, A. (2010). Improvement of Physicochemical Characteristics and Dissolution Profile of Poorly Water Soluble Drug: Ketoprofen by Solid Dispersion Technique. Int.J.Res.Pharm.Sci, 1, 450.

The United State of Pharmacopeia edisi 30. (1995). New York: United State Pharmacopeial Convertion Inc.

Voight, R. (1994). Buku pelajaran teknologi farmasi, Edisi V, Penerjemah Soewandi Noerono, Yogyakarta: Gajah Mada University Press.

Watson, D. G. (2010). Analisis farmasi, Edisi 2. Penerjemah: Winny R. Syarief. Jakarta : Penerbit Buku Kedokteran EGC.




DOI: http://dx.doi.org/10.52689/higea.v6i1.96

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc-sa4.footer##